TRPC channels as STIM1-regulated store-operated channels

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Receptor-induced Ca(2+) signals are key to the function of all cells and involve release of Ca(2+) from endoplasmic reticulum (ER) stores, triggering Ca(2+) entry through plasma membrane (PM) "store-operated channels" (SOCs). The identity of SOCs and their coupling to store depletion remain molecular and mechanistic mysteries. The single transmembrane-spanning Ca(2+)-binding protein, STIM1, is ...

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ژورنال

عنوان ژورنال: Cell Calcium

سال: 2007

ISSN: 0143-4160

DOI: 10.1016/j.ceca.2007.03.004